depakine

Valproic Acid and Mitochondria

Valproic acid (VPA) is known to induce mitochondrial dysfunction, primarily through its interference with mitochondrial beta-oxidation, which can lead to liver toxicity and steatosis. This effect is attributed to VPA’s structural resemblance to fatty acids, allowing it to enter mitochondria and generate a coenzyme A ester (VPA-CoA) […]