Neurobiology of SSRI-Induced Blunted Affect
Selective Serotonin Reuptake Inhibitors (SSRIs) can produce emotional blunting or flattened affect in a substantial subset of patients. This phenomenon involves complex neurobiological mechanisms across multiple systems: Serotonergic Mechanisms Direct 5-HT Effects Regional 5-HT Imbalance Dopaminergic System Interactions Mesolimbic Reward Circuit Mesocortical Pathway Glutamatergic and GABAergic […]
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