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17
Jun
2025
Eye Signs in different Psychiatric Disorders
Posted On June 17, 2025  By [email protected]  And has No Comment

Eye signs and symptoms provide valuable diagnostic and monitoring information across various psychiatric disorders. Here’s an in-depth analysis of these ocular manifestations: Schizophrenia Smooth Pursuit Eye Movement (SPEM) Abnormalities: Deficits in smooth pursuit and an excess of ‘jerky’ eye movements were one of the earliest reported […]

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15
Jun
2025
تحليل خط اليد بالقلم الذكي لتشخيص باركنسون
Posted On June 15, 2025  By [email protected]  And has No Comment

طور مهندسو الطب الحيوي قلمًا معززًا بالذكاء الاصطناعي (AI) لتحليل خط اليد للمساعدة في التشخيص المبكر لمرض باركنسون (PD). في دراسة تجريبية أجريت على ثلاثة مرضى PD و13 مشاركًا أصحاء، حقق القلم دقة بنسبة 96.22% في التمييز بين PD والكتابة اليدوية غير PD. يستخدم القلم طرفًا […]

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23
May
2025
Sulpiride and AmiSulpiride is there a a clinical difference ?
Posted On May 23, 2025  By [email protected]  And has No Comment

Sulpiride and amisulpride are both benzamide antipsychotics primarily used in the treatment of schizophrenia and, in some cases, depression or anxiety disorders. Despite their similarities, they have important differences in structure, pharmacodynamics, and clinical applications. 🔬 Core Molecular Differences Property Sulpiride Amisulpride Chemical Class Substituted benzamide […]

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18
May
2025
Dialectical Behavior Therapy (DBT) Techniques for Borderline Personality Disorder
Posted On May 18, 2025  By [email protected]  And has No Comment

DBT DBT, developed by Dr. Marsha Linehan, is considered the gold standard treatment for Borderline Personality Disorder (BPD). Here are the core techniques and components: Core Modules and Skills 1. Mindfulness Skills 2. Distress Tolerance 3. Emotion Regulation 4. Interpersonal Effectiveness Treatment Structure 1. Individual Therapy […]

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18
May
2025
Comparison of Long-Acting Injectable (LAI) Antipsychotic Medications
Posted On May 18, 2025  By [email protected]  And has No Comment

First-Generation LAIs Haloperidol Decanoate (Haldol Decanoate) Fluphenazine Decanoate (Prolixin Decanoate) Second-Generation LAIs Risperidone Microspheres (Risperdal Consta) Paliperidone Palmitate (Multiple Formulations) Aripiprazole LAIs Olanzapine Pamoate (Zyprexa Relprevv) Comparative Factors Efficacy Rankings Metabolic Profile (Best to Worst) EPS Risk (Lowest to Highest) Prolactin Elevation (Lowest to Highest) Convenience […]

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18
May
2025
Why did Olanzapine Long-Acting Antipsychotics fail to continue?
Posted On May 18, 2025  By [email protected]  And has No Comment

Olanzapine pamoate (Zyprexa Relprevv) actually does exist as a long-acting injectable (LAI) antipsychotic, but it has had a more limited clinical adoption compared to other LAIs for several important reasons: This combination of safety concerns, logistical requirements, and market competition limited the widespread adoption of olanzapine […]

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09
May
2025
Neurobiology of SSRI-Induced Sexual Dysfunction
Posted On May 9, 2025  By [email protected]  And has No Comment

SSRI-induced sexual dysfunction affects approximately 40-70% of patients and involves complex neurobiological mechanisms across multiple systems governing sexual response. The underlying pathophysiology encompasses several interrelated mechanisms: Serotonergic Mechanisms 5-HT Receptor Subtypes Serotonergic Projections Downstream Neurotransmitter Effects Dopaminergic System Cholinergic System Nitric Oxide Pathway Neuroendocrine Mechanisms Hypothalamic-Pituitary-Gonadal […]

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09
May
2025
Neurobiology of SSRI-Induced Blunted Affect
Posted On May 9, 2025  By [email protected]  And has No Comment

Selective Serotonin Reuptake Inhibitors (SSRIs) can produce emotional blunting or flattened affect in a substantial subset of patients. This phenomenon involves complex neurobiological mechanisms across multiple systems: Serotonergic Mechanisms Direct 5-HT Effects Regional 5-HT Imbalance Dopaminergic System Interactions Mesolimbic Reward Circuit Mesocortical Pathway Glutamatergic and GABAergic […]

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09
May
2025
Neurobiology of Anhedonia
Posted On May 9, 2025  By [email protected]  And has No Comment

Anhedonia —the reduced ability to experience pleasure—represents a complex neurobiological phenomenon involving multiple brain circuits, neurotransmitter systems, and molecular mechanisms. Here’s a comprehensive overview: Core Neural Circuits Reward Processing Network Corticolimbic Networks Neurotransmitter Systems Dopaminergic Mechanisms Serotonergic Contributions Other Neurotransmitter Systems Molecular and Cellular Mechanisms Neuroplasticity […]

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06
May
2025
Extended-release formulations of psychotropic medications
Posted On May 6, 2025  By [email protected]  And has No Comment

Several pharmaceutical technologies are employed to create extended-release formulations of psychotropic medications like quetiapine, paliperidone, venlafaxine (Effexor), and paroxetine (Seroxat/Paxil). Here’s an overview of the key technologies used: Matrix Systems Osmotic Pump Technologies Multiparticulate Systems Specialized Coating Technologies Specific Examples These technologies allow for once-daily dosing, […]

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