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Folic, folinic, and methyl folate are not the same

Folic acid and folinic acid are both forms of Vitamin B9 but differ significantly in structure, metabolism, and clinical use.  Folic acid is a synthetic, fully oxidized form found in supplements and fortified foods that requires conversion by the enzymes DHFR and MTHFR to become active.  Folinic acid (also known as leucovorin) is a […]